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Persistent and/or an increased amount of protein in the urine may indicate kidney damage or disease.

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If there is a large amount of protein in the first sample, repeat testing will be ordered.

When investigating the reason, a healthcare practitioner may order additional laboratory tests, such as: See the article on Proteinuria for more on follow-up tests.

If kidney disease or damage is suspected, the healthcare practitioner may also order imaging scans (ultrasonography or CT scan) to evaluate the appearance of the organ.

A urine protein to creatinine ratio (UP/CR) may be ordered on a random urine sample if there is evidence of significant and persistent protein in the urine.

Children and sometimes adults occasionally have some degree of transient proteinuria without apparent kidney dysfunction and may release more protein into their urine during the day than at night.

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